Persistent renal failure (PRF) is a serious complication of acute pancreatitis (AP), a common and complex abdominal condition. This study aimed to explore the predictive value of early lactate and lactate dehydrogenase (LDH) levels for PRF in AP patients.
The study analyzed a large sample of AP patients, dividing them into a PRF group and a non-PRF group. Multivariate analysis revealed that lactate and LDH were significant risk factors for PRF. Stratified analysis showed that patients with LDH levels of 700 U/L or higher and lactate levels of 2 mmol/L or higher had a higher incidence of PRF.
The study found that the combination of lactate and LDH levels had the highest diagnostic accuracy for PRF. The high-risk group, defined as having LDH levels above 700 U/L and lactate levels above 2 mmol/L, had a significantly higher incidence of PRF compared to the low-risk group.
The results suggest that monitoring lactate and LDH levels within 24 hours of admission can help clinicians identify high-risk AP patients early and guide treatment decisions. This study provides valuable insights for improving the prognosis of AP patients by offering a practical tool for risk stratification and early diagnosis of PRF.
